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New scientific research published - The a2 Milk Company

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New scientific research published

November 15, 2017

Study reports A1 protein in conventional milk may trigger symptoms associated with milk intolerance

Beijing: A clinical trial conducted in China and involving 600 adult Han Chinese participants with self-reported lactose intolerance has reported that consumption of a2 Milk™ containing only A2 beta casein reduced acute gastrointestinal symptoms compared to consuming conventional milk containing A1 and A2 beta casein proteins. The study authors say that their findings demonstrate that, in some individuals with self-reported lactose intolerance, the adverse gastrointestinal symptoms following consumption of regular milk may be related to the presence of A1 beta casein protein rather than lactose itself: Nutrition Journal.

The double-blind, randomised, cross-over and peer-reviewed study, published in the UK-based Nutrition Journal, investigated the “acute” impacts of drinking 300ml of milk on symptoms often associated with milk intolerance, with the effects being measured at 1, 3 and 12 hours. All of the participants were non-regular milk drinkers who had not consumed milk for at least four weeks prior to the trial, and who self-reported as lactose intolerant. Participants who drank A1 protein-free milk (a2 Milk™) during the clinical trial showed improvements in gastrointestinal symptoms when they consumed milk containing only A2 beta casein as compared with their consumption of conventional milk. The study was run through international contract research organisation (CRO) SPRIM and was sponsored by The a2 Milk Company.

The participants were chosen from 1,200 consumers who had self-diagnosed lactose intolerance and digestive discomfort after consuming conventional milk. Two hundred participants were then selected from each of three major Chinese cities: Shanghai, Beijing and Guangzhou. Of the 600 self-diagnosed participants, 71% were confirmed as lactose malabsorbers, reflecting a compromised ability to digest lactose.

The authors concluded that: “milk-related gastrointestinal symptoms may result from the ingestion of A1 beta casein rather than lactose in some individuals”. They also stated: “These results suggest that the elimination of A1 beta casein from the diet was associated with reduced severity of acute gastrointestinal symptoms after milk intake in this population.”

Emeritus Professor Robert (Bob) Elliott, The University of Auckland, Department of Paediatrics said: “Often many Chinese adults experience unpleasant bowel symptoms after drinking even one glass of milk. This is often attributed to poor digestion of the milk sugar lactose. In this study of many Chinese people who suffer such milk intolerance, two milks of identical lactose content but different beta casein was tried. Obviously A1 beta casein is often to blame for the symptoms rather than lactose alone. This suggests A1 beta casein in some way irritates the gut.”

“This adds to the intrigue of what lactose intolerance actually is and suggests there’s a role for different dairy proteins in determining how people react to milk.”

Lead investigator of the research Yue Xin Yang said: “It is interesting to see this data showing that dairy proteins can influence digestive symptoms, especially because we know 70% of the world’s population report as being lactose intolerant. Put simply, the study suggests consuming conventional milk may trigger lactose intolerance type symptoms in those people.”


Watch Professor Dennis Savaiano’s view of the newly published science and commentary on his research into rethinking lactose intolerance. 

The paper was presented recently in Beijing: 

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